姓 名 阎松
职 称 副教授
所学专业 海洋生物学
研究方向 环境微生物学
联系电话0411-84105506
学习工作经历
1993.9—1997.7 辽宁师范大学生物系，理学学士
1999.9—2002.7 大连水产学院，农学硕士
2003.2—2006.2 中国科学院海洋研究所，理学博士
2009.1—2012.5 山东省生物药物研究院博士后科研工作站,
中科院海洋所博士后科研流动站博士后研究
1997.9—1999.8 大连自然博物馆，研习员
2006.3—至今 大连交通大学环境与化学工程学院，教师
承担项目情况
1. 主持国家自然科学基金青年科学基金，项目名称：厌氧氨氧化菌特征代谢酶HZO的纯化性质及催化机制研究，课题编号：51408094，起止时间：2015.1-2017.12
2. 主持中国博士后基金项目，项目名称：嗜盐脂肪酶HaLIP的分子结构与嗜盐机制的关系研究，课题编号：20100471579，起止时间：2010.7-2012.7
3.白首乌内生真菌及其抗肿瘤次生代谢产物的研究，国家自然科学基金青年科学基金（21502014），2016.1-2018.12，4/5
4. 利用污水培养高油脂微藻研究，辽宁省教育厅科学研究项目（L2015091），2015.6-2017.12，3/5
5. 膜曝气分离单级自养脱氮生物反应器过程控制和功能菌群研究，国家自然科学基金青年科学基金 （21007006），2011.1-2013.12， 3/6
6. 海洋厌氧光合细菌和硫酸盐还原细菌中活性先导化合物的研究，国家863高技术研究发展计划，2007.1-2009.12， 2/11
发表论文著作情况
1.Song Yan, Xiukun Lin, Xiaorui Chen and Shoutong Zhang. Purification and characterization of an esterase from Halobacillustrueperi whb27. J Pure ApplMicrobio, 2014,Vol. 8(1): 1-9
2. Yan Song, Wang Zheng, Yang Shao-li, Zhang Yi & Lin Xiu-kun. Method of mRNA display for selecting peptides that bind with target enzyme RNA. 3rd International Conference on Bioinformatics and Biomedical Engineering（iCBBE2011）, May 10-12, 2011 Wuhan, China (EI:20112814140883)
3.Yan Song, Chen Lei, Zhu Yanhua,Guo Haiyan, Lin Xiukun. Study on biological treatment of saline wastewater using halophile. 2011 International Conference on Energy and Environment (ICEE2011), January 27~28, 2011
4.Yan Song, Li Xia, Mu Jun, Guo Zhen. Ultrastructural and histochemical observation on the development of oocytes of Haliotis discus hannai. 2010 International Conference on Cellular, Molecular, Biology, Biophysics and Bioengineering(CMBB 2010), December 25 ~26, 2010
5.Song Yan, Zheng Wang, Hong-li Lv, Zhen Guo1 &Xiu-kun Lin. Optimization of mRNA display for identifying peptides that bind with thymidylate synthase RNA. 3rd International Conference on Bioinformatics and Biomedical Engineering（iCBBE2009）, June 11-13, 2009 Beijing, China (EI: 20095312597203)
6.YAN Song, NIU Rongli, WANG Zheng & LIN Xiukun. In vitro selected peptides bind with thymidylate synthase mRNA and inhibit its translation. SciChinaSer C-Life Sci, 2007, 50(5): 630–636
7. 阎松，张翼，王珊珊. 抗生活性中度嗜盐菌的筛选及菌种鉴定.大连交通大学学报，2015，36(S1): 115-118.
8. 阎松，陈雷，林秀坤. 微生物嗜盐酶盐适应性的分子结构基础研究. 中国细胞生物学学报，2012, 34(1): 91–97
9. 阎松，张翼，吕红丽，董学伟，唐超，穆军. 体外展示技术. 生物医学工程学杂志，2009，26(6): 1367-1371
10.阎松，牛荣丽，张培军，林秀坤. 运用mRNA体外展示技术筛选胸苷酸合成酶RNA亲和肽. 生物化学与生物物理进展, 2005, 32(11): 1081-1087.（SCI）
11.阎松，牛荣丽，CHU Edward, 林秀坤. 胸苷酸合成酶表达调控的分子机制. 细胞生物学杂志，2005， 27：105-108
12.阎松，李霞，张国范. 二倍体和三倍体皱纹盘鲍精子发生过程的超微结构. 水产学报，2005，29(3)： 289-295
13.Yang SL, Yan S, Niu RL, Lin XK. VEGF gene silencing by cytomegalovirus promoter driven shRNA expression vector results in vascular development defects in zebrafish. Russian Journal of Genetics, 2009 ,45(9): 1187-1193
14.Yang SL, Yan S, Qin S, Lin XK. Suppression of zebrafish VEGF gene by cytomegalovirus promoter-driven short hairpin constructs induces vascular development defects and down regulation NRP1 expression. Biologia, Section Cellular and Molecular Biology, 2009, 64(5): 1025-1031
15.杨少丽，阎松，郑兰红，王征，林秀坤. 斑马鱼VEGF基因的siRNA表达载体构建、有效序列筛选及其对基因表达的干预性研究. 生物物理学报, 2007，23(5): 364–370
16.牛荣丽，阎松，杜长青，林秀坤. 抗肿瘤新药研究的新型模式生物斑马鱼.中国新药杂志，2006.15 (7)：496-500
17.李霞，阎松，张国范，王子臣. 三倍体皱纹盘鲍性腺发育的生物学研究. 海洋与湖沼，2004，35(1)： 84-88
专利情况
胸苷酸合酶mRNA干扰肽作为肿瘤治疗剂的应用申请号：200710013993；公开(公告)号CN101058599 3/4
教学情况
讲授课程：环境工程微生物学，环境工程微生物学实验，环境生物工程，无机化学实验
教研情况
1. 环境工程微生物学校级课程评价与考核改革专项 2015.1—2017.12 主持
2. 环境工程微生物学校级优秀课 2012.3.1-2013.4.1 2/4
Name: Song Yan
Academic Title: Associate Professor
Speciality: Marine biology
Focus of Research:Environmental microbiology
Tel: 0411-84105506
E-mail: yansong209@aliyun.com
Education and Work Experiences
1993.9—1997.7 Biology Department, Liaoning Normal University, Bachelor of Science.
1997.9—1999.8 Dalian Natural History Museum, Research Assistant
1999.9—2002.7 Dalian Fisheries University, Master of Science in Agriculture
2003.2—2006.2 Institute of Oceanology, Chinese Academy of Sciences, PhD
2006.3— School of Environmental and Chemical Engineering，Dalian Jiaotong
University
Project Development
1.Purification，characterization and catalytic mechanism of hydrazine-oxidizing enzyme from anammox bacteria.National Natural Science Foundation of China(51408094), 2015.1-2017.12
2.Haloadaptation: Insignts from structure studies of halophilic lipase, HaLIP, China Postdoctoral Science Foundation(20100471579), 2010.7-2012.7
Publications
1．Song Yan, Xiukun Lin, Xiaorui Chen and Shoutong Zhang. Purification and characterization of an esterase from Halobacillustrueperi whb27. J Pure ApplMicrobio, 2014,Vol. 8(1): 1-9
2.Yan Song, Wang Zheng, Yang Shao-li, Zhang Yi & Lin Xiu-kun. Method of mRNA display
for selecting peptides that bind with target enzyme RNA. 3rd International Conference on
Bioinformatics and Biomedical Engineering（iCBBE2011）, May 10-12, 2011 Wuhan,
China (EI: 20112814140883)
3. Yan Song, Chen Lei, Zhu Yanhua,Guo Haiyan, Lin Xiukun. Study on biological treatment
of saline wastewater using halophile. 2011 International Conference on Energy and
Environment (ICEE2011), January 27~28, 2011
4. Yan Song, Li Xia, Mu Jun, Guo Zhen. Ultrastructural and histochemical observation on the
development of oocytes of Haliotis discus hannai. 2010 International Conference on
Cellular, Molecular, Biology, Biophysics and Bioengineering(CMBB 2010), December 25
~26, 2010
5. Song Yan, Zheng Wang, Hong-li Lv, Zhen Guo1 &Xiu-kun Lin. Optimization of mRNA
display for identifying peptides that bind with thymidylate synthase RNA. 3rd International
Conference on Bioinformatics and Biomedical Engineering（iCBBE2009）, June 11-13,
2009 Beijing, China (EI: 20095312597203)
6. YAN Song, NIU Rongli, WANG Zheng & LIN Xiukun. In vitro selected peptides bind
with thymidylate synthase mRNA and inhibit its translation. Sci China Ser C-Life Sci, 2007,
50(5): 630–636
7.YAN Song, ZHANG Yi, WANG Shang-shang. Isolation and identification of antibiotic moderately halophilic bacteria.Journal of Dalian Jiaotong University, 2015，36(S1): 115-118.
8.Yan Song, Chen Lei, Lin Xiukun. Molecular Structural Basis of Microbial Halophilic Enzymes Related toTheir Haloadaptation. Chinese Journal of Cell Biology 2012, 34(1): 91–97
technologies, Journal of Biomedical Engineering,2009, 26(6): 1367-1371
10. YAN Song, NIU Rongli, ZHANG Peijun, LIN Xiukun. Identification of peptides that bind
with thymidylate synthase RNA using mRNA display technique. ProgBiochemBiophys,
2005, 32(11): 1081-1087
11. YAN Song, NIU Rongli, CHU Edward, LIN Xiukun. Molecular mechanisms regulating the
expression of thymidylate synthase. Chinese Journal of Cell Biology, 2005，27：105-108
12. YAN Song, LI Xia, ZHANG Guofan. Ultrastructure of diploid and triploid abalones,
Haliotis discus hannai,during spermatogenesis. Journal of Fisheries of China, 2005，29
(3)：289-295
13.Yang SL, Yan S, Niu RL, Lin XK. VEGF gene silencing by cytomegalovirus promoter
driven shRNA expression vector results in vascular development defects in zebrafish.
Russian Journal of Genetics, 2009 ,45(9): 1187-1193
14. Yang SL, Yan S, Qin S, Lin XK. Suppression of zebrafish VEGF gene by
cytomegalovirus promoter-driven short hairpin constructs induces vascular development
defects and down regulation NRP1 expression. Biologia, Section Cellular and Molecular
Biology, 2009, 64 (5): 1025-1031
15. YANG Shaoli, YAN Song, ZHENG Lanhong, WANG Zheng, LIN Xiukun. Construction
and screening efficient VEGF siRNA expression vector in zebrafish. ActaBiophysica
sinica, 2007，23(5): 364–370
16. NIU Rongli, YAN Song, DU Changqing, LIN Xiukun. Zebrafish: a new model for anti-
cancer agents. Chinese Journal of New Drugs, 2006.15(7)：496-500
17. LI Xia, YAN Song, ZHANG Guofan, WANG Zichen. The Biology of Gonadlal
Development of Triploidy Abalone (Haliotis discus hannai). Oceanologia ET Limnologia
Sinica, 2004，35(1)：84-88